Colloquium_21_10-19 David Gerard_edited
From Richard Ressler
Speaker: Dr. David Gerard
Date: Tuesday October 19th, 2021
Abstract: Many bioinformatics pipelines include tests for equilibrium. Tests for diploids are well studied and widely available but extending these approaches to autopolyploids is hampered by the presence of double reduction, the co-migration of sister chromatid segments into the same gamete during meiosis. Though a hindrance for equilibrium tests, double reduction rates are quantities of interest in their own right, as they provide insights about the meiotic behavior of autopolyploid organisms. Here, we develop procedures to (i) test for equilibrium while accounting for double reduction, and (ii) estimate double reduction given equilibrium. To do so, we take two approaches: a likelihood approach, and a novel U-statistic minimization approach that we show generalizes the classical equilibrium χ2 test in diploids. Our methods are implemented in the hwep R package on the Comprehensive R Archive Network https://cran.r-project.org/package=hwep.
The talk will be based on the author’s new preprint: https://doi.org/10.1101/2021.09.24.461731
The host is Dr. Steven Casey, American University